Dr. Idriss Major Fade Hyper Serum Refills
How to refill the Hyper Serum applicator with a new cartridge
Close-up of Major Fade Hyper Serum being applied to skin to visibly brighten dark spots and boost glow
Major Fade Hyper Serum clinical results showing improved skin brightness, more even-looking tone, and reduced dark spots
Major Fade Hyper Serum ingredient highlights featuring kojic acid, alpha arbutin, niacinamide, and diglucosyl gallic acid
How to apply Major Fade Hyper Serum morning and night for dark spots and uneven skin tone
Dr. Shereene Idriss skincare tips for using Hyper Serum under makeup, on body discoloration, and under eyes
AM and PM skincare layering routine featuring Hyper Serum, Active Seal, Flash Mask, Soft Wash, and Disco Block SPF 50
Dr. Shereene Idriss holding Major Fade Hyper Serum with quote about treating discoloration at the source
Major Fade Hyper Serum and Active Seal moisturizer routine for dark spots and uneven skin tone
Customer reviews for Major Fade Hyper Serum highlighting improvements in post-acne marks, dark spots, and skin glow
Comparing the Left Un-Red Reducer Serum to the Major Fade Hyper Serum
Dr. Idriss Major Fade Hyper Serum Refills
How to refill the Hyper Serum applicator with a new cartridge
Close-up of Major Fade Hyper Serum being applied to skin to visibly brighten dark spots and boost glow
Major Fade Hyper Serum clinical results showing improved skin brightness, more even-looking tone, and reduced dark spots
Major Fade Hyper Serum ingredient highlights featuring kojic acid, alpha arbutin, niacinamide, and diglucosyl gallic acid
How to apply Major Fade Hyper Serum morning and night for dark spots and uneven skin tone
Dr. Shereene Idriss skincare tips for using Hyper Serum under makeup, on body discoloration, and under eyes
AM and PM skincare layering routine featuring Hyper Serum, Active Seal, Flash Mask, Soft Wash, and Disco Block SPF 50
Dr. Shereene Idriss holding Major Fade Hyper Serum with quote about treating discoloration at the source
Major Fade Hyper Serum and Active Seal moisturizer routine for dark spots and uneven skin tone
Customer reviews for Major Fade Hyper Serum highlighting improvements in post-acne marks, dark spots, and skin glow
Comparing the Left Un-Red Reducer Serum to the Major Fade Hyper Serum
(Video) Dermatologist Dr. Shereene Idriss explains how to use Hyper Serum and its key benefits
  • Bestseller

Hyper Serum Refills™

Two refill cartridges of our hyperpigmentation serum for dullness, dark spots and post-acne marks. For results that keep going.

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(1248)
For anyone who already owns the Hyper Serum™ pen
Two fresh, sealed cartridges of the same formula
Stay stocked so spots don't come back
Alpha-arbutin + kojic acid target spots at the pigment level
Size
Full Size 0.96 oz/28 ml
Refills 0.96 oz/28 ml
Travel 0.51 oz/15 ml
Without a doubt the best serum I've tried in my LIFE!!! Solved all my issues from dark spots, dehydration & dullness. On my 3rd refill.
  • Dark spots
  • Dullness
Asya A Verified Buyer

Two refill cartridges for the Hyper Serum pen you already own.

Dark spots fade with a consistent routine, and come back when you stop. Keep your routine going without a gap.

  • Same formula as Hyper Serum
  • Two sealed cartridges keep actives fresh
  • Less packaging than a new pen
  • Keeps your routine uninterrupted

How to refill: Twist serum to ON position. Pull back to remove empty cartridge. Insert new cartridge until it snaps into place. Twist between ON/OFF positions.

Application: Twist the push-button counterclockwise to the ON position, and then click to dispense 2-4 pumps per application. Gently massage serum all over face.

Frequency of use: Apply morning and night on clean, dry skin.

Part of your routine: For best results, use with Major Fade Flash Mask, and Major Fade Active Seal.
  • Byrdie Beauty Award 2023
  • Glamour Beauty Award 2023
  • TZR Beauty Groundbreakers 2024
  • Women's Health Skincare Award 2023
  • WWD Insider's Icons Award 2023
  • WWD Greatest Skincare 2024
“I created Major Fade Hyper Serum after years of treating patients struggling with stubborn discoloration, post acne marks, and uneven skin tone. Having personally dealt with melasma myself, I know how frustrating persistent pigmentation can be. My targeted brightening serum helps visibly fade discoloration while supporting healthy, radiant skin.”
Dr. Shereene Idriss Board-certified dermatologist
Major Fade Active Seal™
Major Fade Active Seal™
Vitamin C + Glutathione moisturizer for dullness + dark spots
$58.00
Major Fade restock bundle with Active Seal and Hyper Serum refill cartridges
Major Fade Restock Bundle™
Hyper Serum Refills + Active Seal Moisturizer
$114.00 ($120 value)

Hyper Serum Refills™

Hyperpigmentation serum refills

$62.00

Same pen. Fresh actives.

Each sealed cartridge keeps alpha-arbutin and kojic acid fresh until you click it in.

  • 0%Agree complexion appears more even-toned*
  • 0%Saw a visible reduction in dark spots*
  • Alpha ArbutinSlows tyrosinase, aka the enzyme that makes pigment, to fade dark spots and even tone
  • Kojic AcidAlso blocks tyrosinase, aka the pigment-making enzyme, to fade stubborn spots
  • NiacinamideSoothes and restores skin’s moisture barrier
  • Diglucosyl Gallic AcidVisibly decreases skin redness

Ingredients list

water/aqua/eau, niacinamide, glycerin, caprylic/capric triglyceride, pentylene glycol, alpha-arbutin, butyrospermum parkii (shea) butter, squalane, cetearyl olivate, dimethicone, cetyl alcohol, sorbitan olivate, kojic acid, diglucosyl gallic acid, glycyrrhiza glabra (licorice) root extract, persea gratissima (avocado) oil, sclerotium gum, xanthan gum, citric acid, sodium phytate, caprylyl glycol, hexylene glycol, ethylhexylglycerin, phenoxyethanol, mica, titanium dioxide (ci 77891)

*Based on a consumer perception study of 105 people using Major Fade Hyper Serum for 2 months.

Dr. Shereene Idriss, MD

“To swap: twist the pen to ON, pull out the empty cartridge and snap in the new one. Empty cartridges can go in curbside recycling where accepted. Check your local guidelines.”

Dr. Shereene Idriss, MD signature

Dr. Shereene Idriss, MD

Board-Certified Dermatologist

FAQs

How do I replace the Major Fade Hyper Serum cartridge?

Twist, pull, snap.

Dr. Shereene Idriss, MD

Twist the pen to ON, pull the empty cartridge back to pop it out, then push the new cartridge in until it snaps into place. Every Hyper Serum comes with two cartridges so the actives stay fresh.

Each cartridge is 0.48 oz. At 2 to 4 pumps twice a day, most people get several weeks per cartridge; your exact mileage depends on how many pumps you use.

Yes, they play well together. Hyper Serum goes on first, then your retinoid, or alternate nights while your skin gets used to both. The one rule: skip your retinoid on Flash Mask nights so you're not overdoing it.

Yes. The refill cartridges are made for the Hyper Serum pen you already own. Twist the pen to ON, pull the empty cartridge out, remove the pin stopper from the new one, and push it in until it snaps into place. If a cartridge ever won't click or dispense, email hello@dridriss.com and we'll make it right.

Run this one by your own doctor, since every pregnancy is different and they know your history. Email hello@dridriss.com and we'll send the full ingredient list so you can go through it together.

Quick swap: twist the pen to ON, pull back to remove the empty cartridge, and push the new one in until it snaps into place. Click a few times to restart the flow.

Usually it just needs a reset. Remove and reseat the cartridge, then click several times; a fresh cartridge can need a few. If it still won't flow, email hello@dridriss.com and we'll replace it.

Active Seal has its own subscribe option at 10 percent off with free shipping, and our team can line its delivery up with your refill schedule. Email hello@dridriss.com or manage it in your account portal and we'll get you set up.

Easy swap: twist the pen to ON, pull the empty cartridge back to pop it out, then push the new one in until it snaps into place. You get two cartridges in every Hyper Serum so your actives stay fresh instead of sitting out in the air.

 More FAQs

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